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Open Virol J. 2010 Jun 18;4:103-8. doi: 10.2174/1874357901004030103.

Herpesvirus vectors for therapy of brain tumors.

Author information

  • 1Department of Pediatrics, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294-0011, USA.

Abstract

Genetically modified, conditionally-replicating Herpes Simplex Virus Type 1 (HSV-1) vectors for the treatment of malignant glioma have provided encouraging results in the handful of Phase I and Phase II clinical trials conducted to date. In recent years, a number of new strategies have been developed to improve anti-tumor activity of these attenuated vectors, through either introduction of foreign gene inserts to enhance tumor killing through a variety of mechanisms, or through combination with existing treatment regimens, including radiation and/or chemotherapeutics. Another promising new approach has been the engineering of novel oncolytic HSV vectors that retain wildtype replication, but are targeted to tumor cells through a variety of mechanisms. This review summarizes the latest advances in herpesvirus-mediated oncolytic therapies from both preclinical results and clinical trials with oncolytic HSV vectors in patients, and their implication for design of future trials.

KEYWORDS:

C134; G207; HSV1716; M032; Oncolytic HSV therapy; R5141; brain tumor; chimeric HSV; glioma; phase I trial; rQNestin34.5; γ1(34.5).

PMID:
20811578
[PubMed]
PMCID:
PMC2930154
Free PMC Article

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