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Curr Opin Ophthalmol. 2010 Nov;21(6):442-6. doi: 10.1097/ICU.0b013e32833f0085.

Recommendations for visual evaluations of patients treated with vigabatrin.

Author information

  • Wills Eye Institute, Neuro-Ophthalmology Service, Thomas Jefferson University Medical College, Philadelphia, Pennsylvania, USA. rcs220@comcast.net

Abstract

PURPOSE OF REVIEW:

Although vigabatrin has been used for many years in Europe, this antiepileptic medication was approved for use in the USA only 1 year ago because of concerns for irreversible peripheral visual field loss that can result in functional visual disability.

RECENT FINDINGS:

Visual function testing involves both subjective and objective techniques, some of which can be standardized across multiple centers. With these subjective and objectives issues as a reference, the current literature about the pathogenesis of vigabatrin visual toxicity is reviewed in order to develop a practical and reliable testing program for detecting peripheral visual field changes early in their course; thereby, hopefully limiting disabling visual field loss.

SUMMARY:

Based upon the existing literature as well as the currently available data about the evaluation of visual function, an algorithm has been developed to serve as a starting point for clinicians to evaluate patients treated with vigabatrin for refractory epilepsy.

PMID:
20811279
[PubMed - indexed for MEDLINE]
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