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Clin Vaccine Immunol. 2010 Nov;17(11):1817-9. doi: 10.1128/CVI.00461-09. Epub 2010 Sep 1.

A heterologous MF59-adjuvanted H5N1 prepandemic influenza booster vaccine induces a robust, cross-reactive immune response in adults and the elderly.

Author information

  • 1Novartis Vaccines and Diagnostics, Via Fiorentina, 1, 53100 Siena, Italy. elena.fragapane@novartis.com

Abstract

Immunogenicity and safety of a booster dose of an MF59-adjuvanted H5N1 vaccine containing 7.5 μg A/turkey/Turkey/1/2005-like (clade 2.2) H5N1 hemagglutinin, given approximately 18 months after primary vaccination with a heterologous strain, were evaluated. The booster vaccine was well tolerated and induced a robust, cross-reactive immune response.

PMID:
20810680
[PubMed - indexed for MEDLINE]
PMCID:
PMC2976095
Free PMC Article

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