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Curr Neurol Neurosci Rep. 2010 Nov;10(6):484-90. doi: 10.1007/s11910-010-0140-4.

The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants.

Author information

  • 1Department of Neurology, 2 Gibson, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA. michafra@mail.med.upenn.edu

Abstract

Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer's disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants of PPA are now recognized: semantic variant, logopenic variant, and nonfluent/agrammatic variant. We discuss recent work characterizing the neurolinguistic, neuropsychological, imaging and pathologic profiles associated with these variants. Improved reliability of diagnoses will be increasingly important as trials for etiology-specific treatments become available. We also discuss the implications of these syndromes for theories of language function.

PMID:
20809401
[PubMed - indexed for MEDLINE]
PMCID:
PMC2963791
Free PMC Article
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