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Diabetes Care. 2010 Dec;33(12):2549-51. doi: 10.2337/dc10-1033. Epub 2010 Aug 30.

Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study.

Collaborators (303)

Bray GA, Chatellier A, Duncan C, Greenway FL, Levy E, Ryan DH, Polonsky KS, Tobian J, Ehrmann D, Matulik MJ, Clark B, Czech K, DeSandre C, Hilbrich R, McNabb W, Semenske AR, Goldstein BJ, Smith KA, Wildman W, Pepe C, Goldberg RB, Calles J, Ojito J, Castillo-Florez S, Florez HJ, Giannella A, Lara O, Veciana B, Haffner SM, Montez MG, Lorenzo C, Martinez A, Hamman RF, Testaverde L, Bouffard A, Dabelea D, Jenkins T, Lenz D, Perreault L, Price DW, Steinke SC, Horton ES, Poirier CS, Swift K, Caballero E, Jackson SD, Lambert L, Lawton KE, Ledbury S, Kahn SE, Montgomery BK, Fujimoto W, Knopp RH, Lipkin EW, Marr M, Murillo A, Trence D, Kitabchi AE, Murphy ME, Applegate WB, Bryer-Ash M, Dagogo-Jack S, Frieson SL, Lambeth H, Lichtermann LC, Otkaei H, Rutledge LM, Sherman AR, Smith CM, Soberman JE, Williams-Cleaves B, Metzger BE, Molitch ME, Johnson MK, Giles MM, Larsen D, Niznik C, Pen SC, Schinleber PA, Nathan DM, McKitrick C, Turgeon H, Abbott K, Altshuler D, Anderson E, Bissett L, Cagliero E, D'Anna K, Delahanty L, Florez JC, Goldman V, Poulos A, Tseng B, Barrett-Connor E, Carrion-Petersen ML, Horne J, Leos D, Mudaliar S, Smith J, Vejvoda K, Pi-Sunyer FX, Lee JE, Foo ST, Hagamen S, Marrero DG, Kelly SM, Ackermann RT, Fineberg ES, Hadden A, Jackson MA, Kirkman MS, Mather KJ, Roach PJ, Wheeler ML, Ratner RE, Aroda V, Shapiro S, Bavido-Arrage C, Gibbs P, Uwaifo G, Wiggins R, Saad MF, Watson K, Botrous M, Jinagouda S, Budget M, Conzues C, Magpuri P, Ngo K, Xapthalamous K, White NH, Das S, Santiago A, Brown AL, Wernimont C, Saudek CD, Whittington T, Clark JM, Greene A, Jiggetts D, Mosley H, Reusing J, Rubin RR, Stephens S, Utsey E, Schade DS, Adams KS, Hemphill C, Hyde P, Butler L, Canady JL, Colleran K, Gonzales Y, Hernandez-McGinnis DA, Katz P, King C, Crandall J, Brown JO, Adorno E, Duffy H, Martinez H, Pompi D, Shamoon H, Walker EA, Wylie-Rosett J, Orchard T, Jeffries S, Kramer MK, Smith M, Kriska A, Pettigrew J, Semler L, Venditti E, Weinzierl V, Arakaki RF, Baker-Ladao NK, Isonaga MK, Bermudez NE, Mau MK, Knowler WC, Cooeyate N, Hoskin MA, Natewa C, Percy CA, Acton KJ, Andre VL, Begay S, Bucca BC, Cook S, Doughty MS, Glass J, Glass M, Hanson RL, Hassenpflug D, Ingraham LE, Kobus KM, Krakoff J, Manus C, McCabe C, Michaels S, Morgan T, Nelson JA, Roy RJ, Smart M, Tonemah DP, Wilson C, Fowler S, Brenneman T, Abebe S, Bamdad J, Barkalow M, Bethepu J, Bezabeh T, Callaghan J, Christophi C, Edelstein SL, Gao Y, Gooding R, Gottlieb A, Grover N, Hoffman H, Jablonski K, Katz R, Kolinjivadi P, Lachin JM, Ma Y, Reamer S, Sapozhnikova A, Sherif H, Temprosa M, Venditti EM, Kriska AM, Semler L, Weinzierl V, Marcovina S, Strylewicz G, Albers J, Prineas RJ, Alexander T, Campbell C, Hall S, Hensley S, Li Y, Mills M, Soliman E, Zhang Z, Danis R, Davis M, Endres R, Elsas D, Johnson S, Armstrong J, Badal D, Baliker J, Benz W, Carr A, Delandais L, Dohm K, Esser B, Fink C, Gama V, Geithman P, Goulding A, Hafford D, Hannan C, Harding T, Hubbard L, Hurtenbach C, Kastorff L, Lang K, LaSee L, Minser W, Morton A, Murach D, Myers D, Nieder M, Pauly C, Pothour M, Reed S, Remm A, Roessler J, Sivesind P, Vargo P, Warren K, Watson S, Fradkin J, Garfield S, Gregg E, Zhang P, Mayer-Davis E, Moran RR, Ganiats T, Sarkin AJ, Florez JC, Altshuler D, de Bakker PI, Franks P, Hanson RL, Jablonski K, Knowler WC, McAteer J, Pollin TI, Shuldiner AR.

Abstract

OBJECTIVE:

To assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS).

RESEARCH DESIGN AND METHODS:

DPP/DPPOS participants were assessed for diabetes every 6 months and for antidepressant use every 3 months in DPP and every 6 months in DPPOS for a median 10.0-year follow-up.

RESULTS:

Controlled for factors associated with diabetes risk, continuous antidepressant use compared with no use was associated with diabetes risk in the placebo (adjusted hazard ratio 2.34 [95% CI 1.32-4.15]) and lifestyle (2.48 [1.45-4.22]) arms, but not in the metformin arm (0.55 [0.25-1.19]).

CONCLUSIONS:

Continuous antidepressant use was significantly associated with diabetes risk in the placebo and lifestyle arms. Measured confounders and mediators did not account for this association, which could represent a drug effect or reflect differences not assessed in this study between antidepressant users and nonusers.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00038727.

[PubMed - indexed for MEDLINE]
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