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Genome Biol. 2010;11(8):216. doi: 10.1186/gb-2010-11-8-216. Epub 2010 Aug 26.

Dosage compensation and the global re-balancing of aneuploid genomes.

Author information

  • 1Adolf-Butenandt-Institute and Centre for Integrated Protein Science (CiPSM), Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.

Abstract

Diploid genomes are exquisitely balanced systems of gene expression. The dosage-compensation systems that evolved along with monosomic sex chromosomes exemplify the intricacies of compensating for differences in gene copy number by transcriptional regulation.

PMID:
20804581
[PubMed - indexed for MEDLINE]
PMCID:
PMC2945780
Free PMC Article

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