Abstract
Two genome-wide association studies for meningococcal disease and tuberculosis identify new loci associated with susceptibility to these infectious diseases. They highlight a role for the acquired and innate immune systems in host control of several human pathogens and demonstrate that denser genotyping platforms and population-specific reference panels are necessary for genetic studies in African populations.
MeSH terms
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Africa
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Communicable Diseases / genetics*
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Communicable Diseases / immunology
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Disease Susceptibility / immunology
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Genetic Predisposition to Disease
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Genetics, Population / trends
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Genome-Wide Association Study* / statistics & numerical data
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Genome-Wide Association Study* / trends
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Host-Pathogen Interactions / genetics
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Host-Pathogen Interactions / immunology
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Humans
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Immunity, Innate / genetics
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Infectious Disease Medicine / methods
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Infectious Disease Medicine / trends*