Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Prev Med. 2010 Nov;51(5):416-20. doi: 10.1016/j.ypmed.2010.08.011. Epub 2010 Aug 27.

Correlates of kidney stone disease differ by race in a multi-ethnic middle-aged population: the ARIC study.

Author information

  • 1Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA. 295523sa@student.eur.nl

Abstract

OBJECTIVE:

To identify correlates of kidney stone disease in white and African American men and women in a population-based longitudinal study starting in four US communities, and to assess differences in correlates across racial groups.

METHODS:

Between 1993 and 1995, 12,161 middle-aged participants of the ARIC Study provided information on history of kidney stone disease. Information on incident kidney stone-related hospitalizations was obtained from ICD codes on hospital discharge records.

RESULTS:

Kidney stone disease was reported by 12.0% of men and 4.8% of women. After multivariable adjustment, prevalent kidney stone disease was significantly (p<0.05) associated with male gender (PR=2.50), increased serum triglycerides (PR=1.07 per SD increase), diabetes (PR=1.27), gallstone disease (PR=1.54), white race (PR=1.67), and region of residence. Male gender (HR=1.70), diabetes (HR=1.98), and hypertension (HR=1.69) were significantly associated (p<0.05) with incident kidney stone-related hospitalizations (n=94). Race-stratified analyses showed stronger associations of prevalent kidney stone disease with increased triglycerides, older age, and gallstone disease in African Americans compared to whites, whereas male gender showed stronger association in whites (all p-interaction<0.05).

CONCLUSION:

We identified novel correlates of kidney stone disease (triglycerides, gallstone disease) and risk factor interactions by race (age, male gender, triglycerides, gallstone disease).

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
20801154
[PubMed - indexed for MEDLINE]
PMCID:
PMC2964449
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk