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Virology. 2010 Nov 10;407(1):120-8. doi: 10.1016/j.virol.2010.07.033. Epub 2010 Aug 30.

Discovering microRNAs from Bombyx mori nucleopolyhedrosis virus.

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  • 1Centre of Excellence for Genetics and Genomics of Silkmoths, Laboratory of Molecular Genetics, Centre for DNA Fingerprinting and Diagnostics, Tuljaguda Complex, Mozamjahi Road, Nampally, Hyderabad 500001, India. jyotis@cdfd.org.in

Abstract

MicroRNAs (miRNAs) have emerged as key players in host-pathogen interaction. Recently, many virus-encoded miRNAs have been identified from different mammalian species. However, the large family of invertebrate viruses of Baculoviridae, which infects diverse species of beneficial insects and agriculture pests, has hardly been investigated for elucidating the role of miRNAs in host-pathogen interaction. In the study reported here, we have identified four Bombyx mori nucleopolyhedrosis virus (BmNPV)-encoded miRNAs using a combination of in silico and experimental methods. Unlike other reported viral miRNAs, the BmNPV-encoded miRNAs identified in the present study were found to be evolutionarily conserved among many closely related baculoviruses. Besides, we have computationally predicted 8 viral and 64 cellular targets of these virus-encoded miRNAs and the putative functions of these targets suggest a key role of viral miRNAs in insect-pathogen interactions by modulating several viral replication genes as well as those involved in host immune defense machinery.

Copyright © 2010 Elsevier Inc. All rights reserved.

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