Adv Appl Microbiol. 2010;73:27-59. doi: 10.1016/S0065-2164(10)73002-1.

Function of protein phosphatase-1, Glc7, in Saccharomyces cerevisiae.

Source

Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, Missouri, USA. cannonj@missouri.edu

Abstract

Budding yeast, Saccharomyces cerevisiae, and its close relatives are unique among eukaryotes in having a single gene, GLC7, encoding protein phosphatase-1 (PP1). This enzyme with a highly conserved amino acid sequence controls many processes in all eukaryotic cells. Therefore, the study of Glc7 function offers a unique opportunity to gain a comprehensive understanding of this critical regulatory enzyme. This review summarizes our current knowledge of how Glc7 function modulates processes in the cytoplasm and nucleus. Additionally, global Glc7 regulation is described.

PMID:: 20800758; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Elsevier Science

Other Literature Sources

Molecular Biology Databases

Saccharomyces Genome Database

Supplemental Content

Save items

Related citations in PubMed

PP1 phosphatase-binding motif in Reg1 protein of Saccharomyces cerevisiae is required for interaction with both the PP1 phosphatase Glc7 and the Snf1 protein kinase. [Cell Signal. 2010]
PP1 phosphatase-binding motif in Reg1 protein of Saccharomyces cerevisiae is required for interaction with both the PP1 phosphatase Glc7 and the Snf1 protein kinase.
Tabba S, Mangat S, McCartney R, Schmidt MC. Cell Signal. 2010 Jul; 22(7):1013-21. Epub 2010 Feb 17.
Ypi1, a positive regulator of nuclear protein phosphatase type 1 activity in Saccharomyces cerevisiae. [Mol Biol Cell. 2008]
Ypi1, a positive regulator of nuclear protein phosphatase type 1 activity in Saccharomyces cerevisiae.
Bharucha JP, Larson JR, Gao L, Daves LK, Tatchell K. Mol Biol Cell. 2008 Mar; 19(3):1032-45. Epub 2008 Jan 2.
Shp1, a regulator of protein phosphatase 1 Glc7, has important roles in cell morphogenesis, cell cycle progression and DNA damage response in Candida albicans. [Fungal Genet Biol. 2012]
Shp1, a regulator of protein phosphatase 1 Glc7, has important roles in cell morphogenesis, cell cycle progression and DNA damage response in Candida albicans.
Hu K, Li W, Wang H, Chen K, Wang Y, Sang J. Fungal Genet Biol. 2012 Jun; 49(6):433-42. Epub 2012 Apr 27.
Review The Yap family and its role in stress response. [Yeast. 2010]
Review The Yap family and its role in stress response.
Rodrigues-Pousada C, Menezes RA, Pimentel C. Yeast. 2010 May; 27(5):245-58.
Review The alcohol dehydrogenases of Saccharomyces cerevisiae: a comprehensive review. [FEMS Yeast Res. 2008]
Review The alcohol dehydrogenases of Saccharomyces cerevisiae: a comprehensive review.
de Smidt O, du Preez JC, Albertyn J. FEMS Yeast Res. 2008 Nov; 8(7):967-78. Epub 2008 May 7.

See reviews... See all...

Cited by 3 PubMed Central articles

The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7). [PLoS One. 2013]
The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7).
Böhm S, Buchberger A. PLoS One. 2013; 8(2):e56486. Epub 2013 Feb 13.
Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination. [J Biol Chem. 2012]
Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination.
Zhang DW, Mosley AL, Ramisetty SR, Rodríguez-Molina JB, Washburn MP, Ansari AZ. J Biol Chem. 2012 Mar 9; 287(11):8541-51. Epub 2012 Jan 10.
Reg1 protein regulates phosphorylation of all three Snf1 isoforms but preferentially associates with the Gal83 isoform. [Eukaryot Cell. 2011]
Reg1 protein regulates phosphorylation of all three Snf1 isoforms but preferentially associates with the Gal83 isoform.
Zhang Y, McCartney RR, Chandrashekarappa DG, Mangat S, Schmidt MC. Eukaryot Cell. 2011 Dec; 10(12):1628-36. Epub 2011 Oct 14.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Function of protein phosphatase-1, Glc7, in Saccharomyces cerevisiae.
Function of protein phosphatase-1, Glc7, in Saccharomyces cerevisiae.
Adv Appl Microbiol. 2010 ;73:27-59. doi: 10.1016/S0065-2164(10)73002-1.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: