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Vaccine. 2010 Oct 18;28(44):7184-92. doi: 10.1016/j.vaccine.2010.08.063. Epub 2010 Aug 26.

Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children.

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  • 1Rochester General Hospital Research Institue, 1425 Portland Avenue, Rochester, NY 14621, USA. michael.pichichero@rochestergeneral.org

Abstract

Development of natural antibodies to 3 nontypeable Haemophilus influenzae (NTHi) outer membrane proteins (D, P6 and OMP26) was prospectively studied in 130 children 6-30 months of age during NP colonization and acute otitis media (AOM). IgG antibody to protein D, P6 and OMP26 increased with age (p<0.001). Serum IgG responses to NP colonization were different for the 3 proteins: protein D responses occurred at a later age than P6, and OMP26 responses were minimal. For all 3 proteins serum antibody levels in the convalescent phase of AOM infection were not as high as after NP colonization. Antibodies to protein D and P6 but not OMP26 were bactericidal.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
20800701
[PubMed - indexed for MEDLINE]
PMCID:
PMC3959881
Free PMC Article
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