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J Biomed Opt. 2010 Jul-Aug;15(4):041513. doi: 10.1117/1.3463008.

In vivo functional retinal optical coherence tomography.

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  • 1Medical University of Vienna, Center of Medical Physics and Biomedical Engineering, Vienna, Austria.


An experimental design for noninvasive assessment of neural retinal tissue function with enhanced sensitivity is presented. By matching the response detection to a defined flicker frequency stimulus similar to heterodyne detection, the response signal will be shifted out of the low-frequency noise and the specificity of response detection will be strongly enhanced. Optimal measurement parameters are discussed, such as the function and timing of the response function to a single flash stimulus. The results indicate responses on the order of 200 ms that have been probed with our frequency-encoded approach using 5 Hz flickering. Preliminary results indicate the feasibility of our measurement concept to assess small changes in reflectivity with enhanced sensitivity. A functional tomogram for response localization and quantification is introduced.

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