Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Occup Environ Med. 2010 Sep;52(9):878-86. doi: 10.1097/JOM.0b013e3181ef7e31.

Formaldehyde and leukemia: an updated meta-analysis and evaluation of bias.

Author information

  • 1Division of Occupational and Environmental Medicine, University of California, San Francisco, CA, USA.

Abstract

OBJECTIVE:

Formaldehyde exposures are common, and data linking these exposures to leukemia have been mixed and controversial. The objective of this analysis is to review the current epidemiologic literature on formaldehyde and leukemia.

METHODS:

We performed an updated meta-analysis focusing on high-exposure groups and myeloid leukemia and included two large recent studies: one involving >25,000 workers in US formaldehyde industries and the other involving a cohort of >13,000 funeral directors and embalmers.

RESULTS:

Formaldehyde was associated with increased risks of leukemia (relative risk = 1.53; 95% confidence interval = 1.11 to 2.21; P = 0.005; 14 studies), specifically myeloid leukemia (relative risk = 2.47; 95% confidence interval = 1.42 to 4.27; P = 0.001; 4 studies).

CONCLUSION:

These findings provide evidence of increased myeloid leukemia risk with exposure to formaldehyde.

PMID:
20798648
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk