N Engl J Med. 1978 Aug 3;299(5):221-6.

Dysfibrinogenemia associated with hepatoma. Increased carbohydrate content of the fibrinogen molecule.

Abstract

Abnormal coagulation studies indicative of a dysfibrinogen were found in the plasma of four of seven patients with malignant hepatoma. The abnormal fibrinogen was characterized by prolonged prothrombin, thrombin and reptilase times and inhibition of the coagulation of normal plasma. Purified fibrinogen revealed abnormalities similar to those in plasma. The functional defect was one of delayed polymerization of the fibrin monomer. The carbohydrate content of the abnormal fibrinogen was increased, and this change was related to the abnormal fibrinogen function. Enzymatic cleavage of sialic acid from the abnormal fibrinogen restored fibrinogen function to normal. This hepatoma-associated dysfibrinogen (acquired dysfibrinogenemia) is similar in many respects to fetal fibrinogen and may represent the presence of a fetal form of fibrinogen in hepatoma.

PMID:: 207986; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Save items

Related citations in PubMed

[Hemostatic studies on acquired abnormal fibrinogenemia in severe liver diseases and umbilical cord blood]. [Hokkaido Igaku Zasshi. 1985]
[Hemostatic studies on acquired abnormal fibrinogenemia in severe liver diseases and umbilical cord blood].
Higuchi A. Hokkaido Igaku Zasshi. 1985 Sep; 60(5):748-62.
Acquired dysfibrinogenemia in a hemophiliac with hepatoma: resolution of fibrinogen dysfunction following chemotherapy. [Cancer. 1981]
Acquired dysfibrinogenemia in a hemophiliac with hepatoma: resolution of fibrinogen dysfunction following chemotherapy.
Ballard JO, Kelly GA, Kukrika MD, Sanders JC, Eyster ME. Cancer. 1981 Aug 1; 48(3):686-90.
Dysfibrinogenemia in a patient with primary hepatoma. First observation of an acquired abnormality of fibrin monomer aggregation. [N Engl J Med. 1969]
Dysfibrinogenemia in a patient with primary hepatoma. First observation of an acquired abnormality of fibrin monomer aggregation.
von Felten A, Straub PW, Frick PG. N Engl J Med. 1969 Feb 20; 280(8):405-9.
Abnormal sialic acid content of the dysfibrinogenemia associated with liver disease. [J Clin Invest. 1978]
Abnormal sialic acid content of the dysfibrinogenemia associated with liver disease.
Martinez J, Palascak JE, Kwasniak D. J Clin Invest. 1978 Feb; 61(2):535-8.
Review Laboratory diagnosis of dysfibrinogenemia. [Arch Pathol Lab Med. 2002]
Review Laboratory diagnosis of dysfibrinogenemia.
Cunningham MT, Brandt JT, Laposata M, Olson JD. Arch Pathol Lab Med. 2002 Apr; 126(4):499-505.

See reviews... See all...

Cited by 3 PubMed Central articles

Hepatic haemangiomata: diagnosis and management. [Arch Dis Child. 1981]
Hepatic haemangiomata: diagnosis and management.
Larcher VF, Howard ER, Mowat AP. Arch Dis Child. 1981 Jan; 56(1):7-14.
Review Paraneoplastic syndromes. [West J Med. 1980]
Review Paraneoplastic syndromes.
Stolinsky DC. West J Med. 1980 Mar; 132(3):189-208.
Acquired heparinlike anticoagulant in a patient with metastatic breast carcinoma. [West J Med. 1985]
Acquired heparinlike anticoagulant in a patient with metastatic breast carcinoma.
Rodgers GM, Corash L. West J Med. 1985 Nov; 143(5):672-5.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Dysfibrinogenemia associated with hepatoma. Increased carbohydrate content of th...
Dysfibrinogenemia associated with hepatoma. Increased carbohydrate content of the fibrinogen molecule.
N Engl J Med. 1978 Aug 3 ;299(5):221-6.

PubMed
Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin ...
Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties.
Cancer Biol Ther. 2010 Nov ;10(10):1027-32. Epub 2010 Nov 15 .

PubMed
Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by...
Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK.
Mol Cell Proteomics. 2010 Dec ;9(12):2853-63. Epub 2010 Aug 26 .

PubMed
Stroke monitoring on a national level: PERFECT Stroke, a comprehensive, registry...
Stroke monitoring on a national level: PERFECT Stroke, a comprehensive, registry-linkage stroke database in Finland.
Stroke. 2010 Oct ;41(10):2239-46. Epub 2010 Aug 26 .

PubMed
Beta-mannosidase deficiency: heterogeneous manifestation in the first female pat...
Beta-mannosidase deficiency: heterogeneous manifestation in the first female patient and her brother.
J Inherit Metab Dis. 1990 ;13(6):867-72.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: