Display Settings:

Format

Send to:

Choose Destination
Schizophr Bull. 1990;16(4):563-5.

Defining treatment refractoriness in schizophrenia.

Author information

  • Dept. of Psychiatry, University Hospital, Cleveland, OH 44106.

Abstract

The criteria for treatment refractoriness for the use of clozapine are necessarily set at a high level because of the potential risk of agranulocytosis with this treatment. However, a more liberal definition should be considered to better appreciate the limitations of current therapies and prepare for switching to the next generation of clozapine-like drugs that do not cause agranulocytosis. It is suggested that failure of therapy to bring about the best premorbid level of functioning be considered as a starting point for treatment-resistance.

PMID:
2077634
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk