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    Photodermatol Photoimmunol Photomed. 1990 Aug;7(4):153-8.

    Photoprotective effect of topical anti-inflammatory agents against ultraviolet radiation-induced chronic skin damage in the hairless mouse.

    Bissett DL, Chatterjee R, Hannon DP.

    Source

    Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239-8707.

    Abstract

    Albino hairless mice (Skh:HR-1) exposed chronically to suberythemal doses of ultraviolet (UV) radiation display visible and histological alterations in the skin. One alteration is an increase in dermal cellularity, including inflammatory cells. This suggested a role for inflammation in chronic photodamage. We evaluated the photoprotective effect of topical hydrocortisone, ibuprofen, and naproxen against photodamage. All 3 agents protected against UVB radiation-induced visible wrinkling, tumor formation, and histological alterations. Hydrocortisone and naproxen were also evaluated for protection against UVA radiation-induced visible skin sagging and histological alterations. Both were very effective. These data indicate that chronic topical application of anti-inflammatory agents provides broad solar UV spectrum photoprotection.

    PMID:
    2076370
    [PubMed - indexed for MEDLINE]

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