Tested a stress process model for predicting mental health symptoms in children of alcoholics (COAs). Stress and mental health measures were completed twice over a 3-month period by 145 high school students, 43 of whom self-identified as COAs. Using structural equation modeling, a stress process model for predicting mental health symptoms in children provided a good fit to the data. COA status was related to higher levels of negative and lower levels of positive events. In turn, positive and negative life events were found to have an immediate, but not a longitudinal, direct effect on adolescent symptomatology.