Effect of verapamil on submissive behavior in gene...[Eur J Pharmacol. 1990]

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1: Eur J Pharmacol. 1990 Oct 23;187(3):507-11.Links

Effect of verapamil on submissive behavior in genetically bred hypercholinergic rats in a water competition test.

Pucilowski O, Overstreet DH, Rezvani AH, Janowsky DS.

Bowles Biomedical Research Laboratory, University of North Carolina School of Medicine, Chapel Hill 27599.

Male hypercholinergic FSL (Flinders Sensitive Line) and control FRL (Flinders Resistant Line) rats were placed on a water deprivation schedule and tested for dominance behavior with FSL/FRL pairs competing for water. FSL rats spent significantly less time drinking than their FRL partners. Acute injection of 10 mg/kg of verapamil, a calcium channel inhibitor, to FSL rats markedly increased their drinking time without influencing water intake in individually tested rats. This effect of the drug was no longer seen after prolonged 4 day treatment. It is suggested that submissiveness of FSL animals in the water competition test might be due to increased fear which is alleviated by verapamil treatment. Tolerance seems to develop to this effect of the drug.

PMID: 2073924 [PubMed - indexed for MEDLINE]

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