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AIDS. 2010 Oct 23;24(16):2583-7. doi: 10.1097/QAD.0b013e32833ead18.

Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.

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  • 1Department of Sexual Health and HIV Medicine, Directorate of Infection, Birmingham Heartlands Hospital, Birmingham, UK.


Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.

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