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Otol Neurotol. 2010 Sep;31(7):1135-43. doi: 10.1097/MAO.0b013e3181eb328a.

Erlotinib for progressive vestibular schwannoma in neurofibromatosis 2 patients.

Author information

  • 1Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, U.S.A. splotkin@partners.org

Abstract

OBJECTIVE:

In vitro treatment of Nf2-deficient cells with epidermal growth factor receptor (EGFR) inhibitors can reduce cellular proliferation. We sought to determine the activity of erlotinib for progressive vestibular schwannoma (VS) associated with neurofibromatosis 2 (NF2).

STUDY DESIGN:

Retrospective case review.

SETTING:

Tertiary referral center.

PATIENTS:

Eleven NF2 patients with progressive VS who were poor candidates for standard therapy.

INTERVENTION:

Erlotinib 150 mg daily.

MAIN OUTCOME MEASURES:

A radiographic response was defined as >or= 20% decrease in tumor volume compared with baseline. A hearing response was defined as a statistically significant increase in word recognition score (WRS) compared with baseline; a minor hearing response was defined as a 10 dB improvement in pure-tone average with stable WRS.

RESULTS:

: Before treatment, the median and mean annual volumetric growth rate for 11 index VS were 26% and 46%, respectively. Among 10 evaluable patients, the median time-to-tumor progression was 9.2 months. Three patients with stable disease experienced maximum tumor shrinkage of 4%, 13%, and 14%. Nine patients underwent audiologic evaluations. One experienced a transient hearing response, 2 experienced minor hearing responses, 3 remained stable, and 2 developed progressive hearing loss. The median time-to-progressive hearing loss was 9.2 months and to either tumor growth or progressive hearing loss was 7.1 months. Adverse treatment effects included mild-to-moderate rash, diarrhea, and hair thinning, with 2 episodes of grade 3 toxicity.

CONCLUSION:

Erlotinib treatment was not associated with radiographic or hearing responses in NF2 patients with progressive VS. Because a subset of patients experienced prolonged stable disease, time-to-progression may be more appropriate than radiographic or hearing response for anti-EGFR agents in NF2-associated VS.

PMID:
20736812
[PubMed - indexed for MEDLINE]
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