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    Dement Geriatr Cogn Disord. 2010;30(2):121-30. doi: 10.1159/000319537. Epub 2010 Aug 21.

    An MRI-based semiquantitative index for the evaluation of brain atrophy and lesions in Alzheimer's disease, mild cognitive impairment and normal aging.

    Chen W, Song X, Zhang Y, Darvesh S, Zhang N, D'Arcy RC, Black S, Rockwood K.

    Source

    National Research Council Canada, Institute for Biodiagnostics (Atlantic), Halifax, N.S., Canada.

    Abstract

    BACKGROUND:

    This study investigates how T(1)-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer's disease (AD) and normal aging.

    METHODS:

    A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets.

    RESULTS:

    The T(1)- and T(2)-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores.

    CONCLUSION:

    The T(1)-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging.

    Copyright © 2010 S. Karger AG, Basel.

    PMID:
    20733305
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2969164
    Free PMC Article

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