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J Am Acad Child Adolesc Psychiatry. 2010 Sep;49(9):898-905.e3. doi: 10.1016/j.jaac.2010.02.014. Epub 2010 May 14.

Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.

Author information

  • 1Massachusetts General Hospital, 55 Fruit Street-Warren 705, Boston, MA 02114, USA. emick1@partners.org

Abstract

OBJECTIVE:

Genes likely play a substantial role in the etiology of attention-deficit/hyperactivity disorder (ADHD). However, the genetic architecture of the disorder is unknown, and prior genome-wide association studies (GWAS) have not identified a genome-wide significant association. We have conducted a third, independent, multisite GWAS of DSM-IV-TR ADHD.

METHOD:

Families were ascertained at Massachusetts General Hospital (MGH; N = 309 trios), Washington University at St. Louis (WASH-U; N = 272 trios), and University of California at Los Angeles (UCLA; N = 156 trios). Genotyping was conducted with the Illumina Human1M or Human1M-Duo BeadChip platforms. After applying quality control filters, association with ADHD was tested with 835,136 SNPs in 735 DSM-IV ADHD trios from 732 families.

RESULTS:

Our smallest p value (6.7E-07) did not reach the threshold for genome-wide statistical significance (5.0E-08), but one of the 20 most significant associations was located in a candidate gene of interest for ADHD (SLC9A9, rs9810857, p = 6.4E-6). We also conducted gene-based tests of candidate genes identified in the literature and found additional evidence of association with SLC9A9.

CONCLUSIONS:

We and our colleagues in the Psychiatric GWAS Consortium are working to pool together GWAS samples to establish the large data sets needed to follow-up on these results and to identify genes for ADHD and other disorders.

2010 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

Comment in

  • The new genetics in child psychiatry. [J Am Acad Child Adolesc Psychiatry. 2010]
PMID:
20732626
[PubMed - indexed for MEDLINE]
PMCID:
PMC3730251
Free PMC Article

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