Bioorg Med Chem Lett. 2010 Oct 1;20(19):5891-4. Epub 2010 Aug 1.

Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists.

Griebenow N, Bärfacker L, Meier H, Schneider D, Teusch N, Lustig K, Kast R, Kolkhof P.

Source

Bayer Schering Pharma AG, Global Drug Discovery, Medicinal Chemistry Wuppertal, Building 460, D-42096 Wuppertal, Germany. nils.griebenow@bayerhealthcare.com

Abstract

Potent and selective adenosine A(1) receptor antagonists were disclosed. SAR and pharmacological profile of selected compounds were discussed.

PMID:: 20728355; [PubMed - indexed for MEDLINE]

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