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Auris Nasus Larynx. 2011 Apr;38(2):240-3. doi: 10.1016/j.anl.2010.07.003. Epub 2010 Aug 19.

Treatment of salivary mucocele of the lower lip by OK-432.

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  • 1Department of Otolaryngology, Yamagata University School of Medicine, 2-2-2, Iida-nishi, Yamagata, Yamagata 990-9585, Japan.



The aim of this paper was to evaluate the outcome and complications of the treatment of patients with salivary mucocele by intralesional injection therapy with OK-432.


We tried OK-432 therapy in 20 patients with salivary mucocele. We injected OK-432 solution into the lesion with a 27-gauge needle to prevent any leakage of the agent from the mucocele.


Disappearance of the lesion was observed in 16 of 20 patients. Marked reduction was observed in 4 of 20 patients. No local scarring or deformity of the lower lip occurred in any patients. As side effects, local discomfort at the injection site was observed in two of the patients, but such problems resolved within a few days. We performed this treatment on an outpatient basis without hospitalization.


Our results confirmed that OK-432 therapy is simple, easy, and relatively safe, and can be used as a substitute for surgery in the treatment of salivary mucocele.

Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

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