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    Mitochondrion. 2011 Jan;11(1):108-18. Epub 2010 Aug 18.

    Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin.

    Thomas RR, Khan SM, Portell FR, Smigrodzki RM, Bennett JP Jr.

    Source

    Morris Udall Parkinson's Disease Research Center of Excellence, University of Virginia, Charlottesville, VA, United States.

    Abstract

    Recombinant human mitochondrial transcription factor A protein (rhTFAM) was evaluated for its acute effects on cultured cells and chronic effects in mice. Fibroblasts incubated with rhTFAM acutely increased respiration in a chloramphenicol-sensitive manner. SH-SY5Y cells showed rhTFAM concentration-dependent reduction of methylpyridinium (MPP(+))-induced oxidative stress and increases in lowered ATP levels and viability. Mice treated with weekly i.v. rhTFAM showed increased mitochondrial gene copy number, complex I protein levels and ATP production rates; oxidative damage to proteins was decreased ~50%. rhTFAM treatment improved motor recovery rate after treatment with MPTP and dose-dependently improved survival in the lipopolysaccharide model of endotoxin sepsis.

    Copyright © 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

    PMID:
    20727424
    [PubMed - indexed for MEDLINE]
    PMCID: PMC3005536
    Free PMC Article

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