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    FEMS Yeast Res. 2010 Nov;10(7):812-8. doi: 10.1111/j.1567-1364.2010.00663.x. Epub 2010 Aug 18.

    A fungicidal piperazine-1-carboxamidine induces mitochondrial fission-dependent apoptosis in yeast.

    Bink A, Govaert G, François IE, Pellens K, Meerpoel L, Borgers M, Van Minnebruggen G, Vroome V, Cammue BP, Thevissen K.

    Source

    Centre of Microbial and Plant Genetics (CMPG), Katholieke Universiteit Leuven, Heverlee, Belgium.

    Abstract

    To unravel the working mechanism of the fungicidal piperazine-1-carboxamidine derivative BAR0329, we found that its intracellular accumulation in Saccharomyces cerevisiae is dependent on functional lipid rafts. Moreover, BAR0329 induced caspase-dependent apoptosis in yeast, in which the mitochondrial fission machinery consisting of Fis1 (Whi2), Dnm1 and Mdv1 is involved. Our data are consistent with a prosurvival function of Fis1 (Whi2) and a proapoptotic function of Dnm1 and Mdv1 during BAR0329-induced yeast cell death.

    PMID:
    20726898
    [PubMed - indexed for MEDLINE]

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