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Cell. 2010 Aug 20;142(4):511-2. doi: 10.1016/j.cell.2010.08.004.

Reversing cachexia.

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  • 1Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.


Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac muscle and increased life span by blocking ActRIIB with a decoy receptor.

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