J Nucl Med. 2010 Sep;51(9):1331-4. doi: 10.2967/jnumed.109.065656. Epub 2010 Aug 18.

Molecular imaging of the dopamine transporter.

Source

Centre for Psychiatry Research, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden. andrea.varrone@ki.se

Abstract

The dopamine transporter (DAT) is a transmembrane protein responsible for reuptake of dopamine from the synaptic cleft and termination of dopaminergic transmission. Several radioligands are available for DAT imaging with SPECT and PET. This review summarizes the main SPECT and PET radioligands and the main applications of DAT imaging in neuropsychiatric disorders.

PMID:: 20720060; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Review SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder. [Expert Rev Neurother. 2008]
Review SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder.
Krause J. Expert Rev Neurother. 2008 Apr; 8(4):611-25.
Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: association between striatal dopamine markers and motor hyperactivity. [Biol Psychiatry. 2005]
Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: association between striatal dopamine markers and motor hyperactivity.
Jucaite A, Fernell E, Halldin C, Forssberg H, Farde L. Biol Psychiatry. 2005 Feb 1; 57(3):229-38.
Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane. [Biol Psychiatry. 2007]
Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane.
Spencer TJ, Biederman J, Madras BK, Dougherty DD, Bonab AA, Livni E, Meltzer PC, Martin J, Rauch S, Fischman AJ. Biol Psychiatry. 2007 Nov 1; 62(9):1059-61. Epub 2007 May 23.
Review The role of DAT-SPECT in movement disorders. [J Neurol Neurosurg Psychiatry....]
Review The role of DAT-SPECT in movement disorders.
Kägi G, Bhatia KP, Tolosa E. J Neurol Neurosurg Psychiatry. 2010 Jan; 81(1):5-12.
Review The dopamine transporter: role in neurotoxicity and human disease. [Toxicol Appl Pharmacol. 2005]
Review The dopamine transporter: role in neurotoxicity and human disease.
Bannon MJ. Toxicol Appl Pharmacol. 2005 May 1; 204(3):355-60.

See reviews... See all...

Cited by 1 PubMed Central article

Drug-induced parkinsonism. [J Clin Neurol. 2012]
Drug-induced parkinsonism.
Shin HW, Chung SJ. J Clin Neurol. 2012 Mar; 8(1):15-21. Epub 2012 Mar 31.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Molecular imaging of the dopamine transporter.
Molecular imaging of the dopamine transporter.
J Nucl Med. 2010 Sep ;51(9):1331-4. doi: 10.2967/jnumed.109.065656. Epub 2010 Aug 18 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: