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J Nucl Med. 2010 Sep;51(9):1331-4. doi: 10.2967/jnumed.109.065656. Epub 2010 Aug 18.

Molecular imaging of the dopamine transporter.

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  • 1Centre for Psychiatry Research, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden. andrea.varrone@ki.se


The dopamine transporter (DAT) is a transmembrane protein responsible for reuptake of dopamine from the synaptic cleft and termination of dopaminergic transmission. Several radioligands are available for DAT imaging with SPECT and PET. This review summarizes the main SPECT and PET radioligands and the main applications of DAT imaging in neuropsychiatric disorders.

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