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EMBO J. 2010 Aug 18;29(16):2753-68. doi: 10.1038/emboj.2010.182.

Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis.

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  • 1Institute of Science and Technology Austria, Klosterneuburg, Austria.

Abstract

Integrin- and cadherin-mediated adhesion is central for cell and tissue morphogenesis, allowing cells and tissues to change shape without loosing integrity. Studies predominantly in cell culture showed that mechanosensation through adhesion structures is achieved by force-mediated modulation of their molecular composition. The specific molecular composition of adhesion sites in turn determines their signalling activity and dynamic reorganization. Here, we will review how adhesion sites respond to mecanical stimuli, and how spatially and temporally regulated signalling from different adhesion sites controls cell migration and tissue morphogenesis.

PMID:
20717145
[PubMed - indexed for MEDLINE]
PMCID:
PMC2924654
Free PMC Article

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