Format

Send to:

Choose Destination
See comment in PubMed Commons below
Oxid Med Cell Longev. 2010 May-Jun;3(3):168-77. doi: 10.4161/oxim.3.3.12106.

Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer.

Author information

  • 1Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.

Abstract

Autophagy is a catalytic process of the bulk degradation of long-lived cellular components, ultimately resulting in lysosomal digestion within mature cytoplasmic compartments known as autophagolysosomes. Autophagy serves many functions in the cell, including maintaining cellular homeostasis, a means of cell survival during stress (e.g., nutrient deprivation or starvation) or conversely as a mechanism for cell death. Increased reactive oxygen species (ROS) production and the resulting oxidative cell stress that occurs in many disease states has been shown to induce autophagy. The following review focuses on the roles that autophagy plays in response to the ROS generated in several diseases.

PMID:
20716941
[PubMed - indexed for MEDLINE]
PMCID:
PMC2952075
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Write to the Help Desk