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J Rheumatol. 2010 Sep;37(9):1828-33. doi: 10.3899/jrheum.091443. Epub 2010 Aug 17.

LupusQoL-US benchmarks for US patients with systemic lupus erythematosus.

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  • 1Department of Medicine and Behavioral Medicine, Rush University, 1611 W. Harrison Street, Chicago, IL 60612, USA.



The LupusQoL-US instrument was recently validated in the US. We studied the benchmarks for a US patient cohort with systemic lupus erythematosus (SLE) and relevant demographic and disease correlates.


LupusQoL-US was administered to 185 patients with SLE. Demographic data (age, sex, ethnicity, marital status) and disease features (duration, disease activity and damage) were assessed simultaneously. Descriptive statistics were obtained. LupusQoL-US domain scores were calculated, and compared by sex, ethnicity, and marital status using nonparametric tests. Correlation between LupusQoL-US domains and age, disease duration, disease activity, and disease damage were obtained.


Mean age of patients was 42.2 +/- 14.5 years; 94% of subjects were women. African American patients comprised 60% of the study cohort. The most affected domains were Fatigue and Physical Health. The least affected was Intimate Relationships. Age correlated with Physical Health, Pain, and Body Image (r = 0.15-0.18). Differences were observed based on sex and marital status, but not by ethnicity; there the LupusQoL-US correlated inversely with disease activity (r = -0.001 to -0.36) and damage (r = -0.003 to -0.40).


All domains of the LupusQoL-US based health related quality of life (HRQOL) were affected adversely. HRQOL varied by age, sex, and marital status in our SLE cohort.

[PubMed - indexed for MEDLINE]
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