Abstract
A water-soluble, pH-responsive copolymer was synthesized successfully and used as a polymeric carrier to deliver hydrophobic paramagnetic nanoparticles into cells. In an acidic environment, the nanoparticles aggregate as the copolymer degrades, resulting in the enhancement of an in vitro MRI signal.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Contrast Media / chemistry*
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Contrast Media / toxicity
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Ferric Compounds / chemistry
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Humans
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Hydrogen-Ion Concentration
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Hydrophobic and Hydrophilic Interactions
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Magnetic Resonance Imaging
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Magnetics
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Metal Nanoparticles / chemistry*
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Metal Nanoparticles / toxicity
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Metal Nanoparticles / ultrastructure
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Polymers / chemistry*
Substances
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Contrast Media
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Ferric Compounds
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Polymers
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ferric oxide