Fluoroglycoproteins: ready chemical site-selective incorporation of fluorosugars into proteins

Chem Commun (Camb). 2010 Nov 21;46(43):8142-4. doi: 10.1039/c0cc01576h. Epub 2010 Aug 16.

Abstract

A tag-and-modify strategy allows the practical synthesis of homogenous fluorinated glyco-amino acids, peptides and proteins carrying a fluorine label in the sugar and allows access to first examples of directly radiolabelled ([(18)F]-glyco)proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorine / chemistry*
  • Fluorine Radioisotopes / chemistry
  • Fucose / analogs & derivatives
  • Fucose / chemistry
  • Glycoproteins / chemistry*

Substances

  • Fluorine Radioisotopes
  • Glycoproteins
  • Fluorine
  • Fucose
  • 2-deoxy-2-fluorogalactose