Display Settings:

Format

Send to:

Choose Destination
Indian J Psychiatry. 2007 Apr;49(2):85-90. doi: 10.4103/0019-5545.33253.

Cellular and molecular mechanisms of drug dependence: An overview and update.

Author information

  • 1Department of Psychiatry, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

Drug dependence is a major cause of morbidity and loss of productivity. Various theories ranging from economic to psychological have been invoked in an attempt to explain this condition. With the advent of research at the cellular and subcellular levels, perspectives on the etiology of drug dependence have also changed. Perhaps the greatest advance has been in the identification of specific receptors for each of the drugs, their target neurotransmitter systems and the intracellular changes produced by them. These receptors also provide potential targets for treatment strategies of drug dependence. This overview attempts to present the mechanisms in the development of dependence and the newer treatment strategies for the major drugs of abuse like alcohol, opioids, cannabis, nicotine and cocaine.

KEYWORDS:

Drug dependence; cellular mechanism; neurotransmitters; receptors

PMID:
20711388
[PubMed]
PMCID:
PMC2917090
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
    Loading ...
    Write to the Help Desk