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Oncogene. 2010 Oct 14;29(41):5556-8. doi: 10.1038/onc.2010.347. Epub 2010 Aug 16.

p66(Shc) and Ras: controlling anoikis from the inside-out.

Author information

  • Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA. Jayanta.Debnath@ucsf.edu

Abstract

Protection from detachment-induced cell death, termed anoikis, facilitates metastasis. Though anoikis is largely attributed to the loss of integrin-related 'outside-in' survival signals, Terada and colleagues demonstrate a novel 'inside-out' attachment sensing role for the adapter protein p66(Shc) in promoting anoikis and suppressing metastasis via Ras-dependent control of proliferation and survival.

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PMID:
20711240
[PubMed - indexed for MEDLINE]
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