Send to

Choose Destination
See comment in PubMed Commons below
Oncogene. 2010 Oct 14;29(41):5556-8. doi: 10.1038/onc.2010.347. Epub 2010 Aug 16.

p66(Shc) and Ras: controlling anoikis from the inside-out.

Author information

  • 1Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA.


Protection from detachment-induced cell death, termed anoikis, facilitates metastasis. Though anoikis is largely attributed to the loss of integrin-related 'outside-in' survival signals, Terada and colleagues demonstrate a novel 'inside-out' attachment sensing role for the adapter protein p66(Shc) in promoting anoikis and suppressing metastasis via Ras-dependent control of proliferation and survival.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk