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Vaccine. 2010 Oct 4;28(42):6915-22. doi: 10.1016/j.vaccine.2010.08.004. Epub 2010 Aug 12.

Circulating pneumococcal specific plasma and memory B cells in the elderly two years after pneumococcal conjugate versus polysaccharide vaccination.

Author information

  • 1Department of Immunology, University College London Medical School, Royal Free Hospital Campus, London NW3 2PF, UK. h.baxendale@medch.ucl.ac.uk

Abstract

BACKGROUND:

Polysaccharide conjugate vaccines prime for lasting memory responses in children and young adults. The potential value of these vaccines in the elderly is unclear.

METHODS:

We compared the frequency of circulating pneumococcal capsular polysaccharide (PPS) specific IgG, IgA and IgM plasma and memory cells by cultured ELISpot and supernatant screening two years after vaccination with the 7-valent pneumococcal conjugate vaccine (7vCRM) and/or the 23-valent pneumococcal polysaccharide vaccine (PPV) in 252 adults aged 50-80 years. Some individuals received a six-month boost with 7vCRM or PPV. PPS specific IgG memory detected two years post-primary vaccination was correlated with published matched serum IgG concentration pre- and up to one year post-primary vaccination.

RESULTS:

There was no difference by vaccine schedule in the quantity of plasma or memory cells detected. The concentration of in vitro PPS IgG produced by memory B cells isolated two years post-vaccination correlated with pre-vaccination serum IgG concentration and not with D28 post-vaccination responses regardless of vaccination schedule.

CONCLUSIONS:

This study shows that circulating memory B cells numbers two years following immunisation with 7vCRM or PPV are best predicted by pre-vaccination serotype specific serum antibody concentration and not early post-vaccination serum antibody responses.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
20708698
[PubMed - indexed for MEDLINE]
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