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J Asian Nat Prod Res. 2010 Aug;12(8):727-30. doi: 10.1080/10286020.2010.493506.

A new ganoderic acid from Ganoderma lucidum mycelia.

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  • 1Key Laboratory of Microbial Metabolism, Ministry of Education, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China.


A new ganoderic acid (GA), 7-O-ethyl ganoderic acid O (GA-O) (1), together with two known compounds, GA-T (2) and GA-Me (3), was isolated and purified from fermented mycelia of Ganoderma lucidum. The structure of the new triterpenoid was elucidated on the basis of the interpretation of extensive spectroscopic data (HR-MS, IR, UV, 1D and 2D NMR) as 3 alpha,15 alpha,22-triacetoxy-7 alpha-ethoxy-5 alpha-lanost-8,24E-dien-26-oic acid. The new compound was found to contain a rare ethoxyl group at C-7. In addition, its cytotoxicity against 95D and HeLa human cancer cell lines was also evaluated.

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