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Indian J Psychiatry. 2006 Apr;48(2):118-20. doi: 10.4103/0019-5545.31603.

Efficacy and tolerability of injectable sodium valproate in patients with mania.

Author information

  • 1Professor and Unit Head-III Department of Psychiatry, SMS Medical College, Jaipur, Rajasthan.

Abstract

BACKGROUND:

Sodium valproate is among the newer mood stabilizers and is also an anticonvulsant.

AIM:

To assess the effect of intravenous sodium valproate in patients with acute manic episodes of bipolar disorder.

METHODS:

A 1-week open trial was conducted in the year 2004-2005 at the emergency ward of the Psychiatric Centre, SMS Medical College, Jaipur, in which 30 patients participated.

CONCLUSION:

Substantial improvement was seen. No major side-effects were noted except marginal elevation of the SGOT and SGPT. The findings suggest that injectable sodium valproate is a safe and effective mood stabilizer for patients with mania.

PMID:
20703399
[PubMed]
PMCID:
PMC2913561
Free PMC Article
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