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Cold Spring Harb Perspect Biol. 2010 Sep;2(9):a002444. doi: 10.1101/cshperspect.a002444. Epub 2010 Aug 11.

Mediation of T-cell activation by actin meshworks.

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  • 1Department of Pathology, University of California, San Francisco, San Francisco, California 94143-0511, USA.

Abstract

Although the actin cytoskeleton and T-cell receptor (TCR) signaling complexes are seemingly distinct molecular structures, they are tightly integrated in T cells. The signaling pathways initiated by TCRs binding to peptide MHC complexes are extensively influenced by the actin cytoskeletal activities of the motile phase before TCR signaling, the signalosome scaffolding function of the cytoskeleton, and the translocation of signaling clusters that precedes the termination of signaling at these complexes. As these three successive phases constitute essentially all the steps consequent to immune synapse formation, it has become clear that the substantial physical forces and signaling interactions generated by the actin cytoskeleton dominate the signaling life cycle of TCR signalosomes. We discuss the contributions of the actin cytoskeleton to TCR signaling phases and model some remaining questions about how specific cytoskeletal factors regulate TCR signaling outcomes.

PMID:
20702599
[PubMed - indexed for MEDLINE]
PMCID:
PMC2926748
Free PMC Article

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