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Bioorg Med Chem Lett. 2010 Sep 15;20(18):5495-8. doi: 10.1016/j.bmcl.2010.07.075. Epub 2010 Jul 21.

[17(20)E]- and [17(20)Z]-pregna-5,17(20)-dien-21-oylamides. Facile synthesis and primary evaluation for cancer cells proliferation.

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  • 1V.N. Orekhovich Institute of Biomedical Chemistry RAMS, Moscow, Russia.


Reaction of 17alpha-bromo-21-iodo-3beta-acetoxypregn-5-en-20-one with ammonia, primary, and secondary amines is simple and convenient method for preparation of [17(20)E]- and [17(20)Z]-pregna-5,17(20)-dien-21-oylamides. Synthesis and characteristics of 12 related amides are presented. Primary testing on cells proliferation indicated differing effects of synthesized compounds on androgen insensitive MCF-7 cells and androgen sensitive LNCaP cells.

Copyright (c) 2010. Published by Elsevier Ltd.

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