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Hypertens Pregnancy. 2010;29(4):399-409. doi: 10.3109/10641950903214633.

Does C-reactive protein predict recurrent preeclampsia?

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  • 1Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, PA, USA.



Evaluate association of the inflammatory marker C-reactive protein with recurrent preeclampsia.


Serum samples collected longitudinally in women with previous preeclampsia from the Maternal-Fetal Medicine Units Network trial of aspirin to prevent preeclampsia were assayed for CRP.


Of 255 women studied, 50 developed recurrence. Baseline C-reactive protein concentration was similar between women who did and did not recur. After adjusting for confounders, neither elevated baseline C-reactive protein nor its change over gestation was associated with recurrence.


In this group of women with previous preeclampsia, neither baseline C-reactive protein concentration nor change in concentration over gestation was associated with recurrent preeclampsia.

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