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Arch Neurol. 2010 Aug;67(8):1018-20. doi: 10.1001/archneurol.2010.167.

Longitudinally extensive transverse myelitis following vaccination with nasal attenuated novel influenza A(H1N1) vaccine.

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  • 1Center for Family Medicine, 1115 E 20th St, Sioux Falls, SD 57105, USA.

Abstract

BACKGROUND:

Transverse myelitis has been reported in association with vaccination, including influenza vaccination.

OBJECTIVE:

To describe a case of longitudinally extensive transverse myelitis associated with vaccination with a nasal attenuated novel influenza A(H1N1) vaccine.

DESIGN:

Case report.

SETTING:

Sanford University of South Dakota Hospital. Patient A 27-year-old woman with longitudinally extensive transverse myelitis.

RESULTS:

Four days following novel influenza A(H1N1) vaccination, the patient developed longitudinally extensive transverse myelitis. Extensive diagnostic evaluation effectively ruled out causes other than vaccination-associated transverse myelitis. Following treatment with corticosteroids and plasmapheresis, the patient made a significant recovery.

CONCLUSIONS:

Transverse myelitis may be associated with vaccination against novel influenza A(H1N1). Additionally, we believe this to be the first report of longitudinally extensive transverse myelitis associated with any vaccine.

PMID:
20697056
[PubMed - indexed for MEDLINE]
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