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Arch Neurol. 2010 Dec;67(12):1442-8. doi: 10.1001/archneurol.2010.191. Epub 2010 Aug 9.

Prospects for minocycline neuroprotection.

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  • 1Department of Cell Biology and Human Anatomy, University of California, Davis, Sacramento, 95817, USA.

Abstract

Minocycline is a clinically available antibiotic and anti-inflammatory drug that also demonstrates neuroprotective properties in a variety of experimental models of neurological diseases. There have thus far been more than 300 publications on minocycline neuroprotection, including a growing number of human studies. Our objective is to critically review the biological basis and translational potential of this action of minocycline on the nervous system.

PMID:
20697034
[PubMed - indexed for MEDLINE]
PMCID:
PMC3127230
Free PMC Article

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