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Neuron. 2010 Aug 12;67(3):359-62. doi: 10.1016/j.neuron.2010.07.026.

A custody battle for the mind: evidence for extensive imprinting in the brain.

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  • 1Department of Anatomy, University of California, San Francisco, MC 2722, CA 94158, USA.


Relatively few genes (approximately 100) have previously been shown to be imprinted such that their expression in progeny derives from either the maternal or paternal copy. Two recent studies by Gregg et al. (2010a, 2010b) in Science expand this list by an order of magnitude, revealing complex patterns of parent-of-origin bias in gene expression in the brain that are developmentally and regionally restricted, and in many cases, sexually dimorphic.

(c) 2010 Elsevier Inc. All rights reserved.

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