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OMICS. 2010 Oct;14(5):501-15. doi: 10.1089/omi.2010.0029. Epub 2010 Aug 9.

Comparative functional genomics of stress responses in yeasts.

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  • 1Dynamique des Structures et Interactions des MacromolĂ©cules Biologiques, INSERM UMR-S 665, UniversitĂ© Paris Diderot, Paris, France.


Systems biology proposes a multidisciplinary approach of biological systems, in order to obtain global and quantitative models of their functioning. This review presents an overview of 10 years of systemic analyses of the cellular responses to environmental stresses, using one of the favorite postgenomics models: the budding yeast Saccharomyces cerevisiae. These analyses include the global reconstruction and the dynamic modeling of the regulatory networks involved in the adaptation of the cells to environmental fluctuations and the extension of these approaches to other yeast species, to provide insights in the mechanisms that drive the evolution of the biological network properties.

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