Artificial antigen-presenting cells for use in adoptive immunotherapy

Cancer J. 2010 Jul-Aug;16(4):374-81. doi: 10.1097/PPO.0b013e3181eb33a6.

Abstract

The observation that T cells can recognize and specifically eliminate cancer cells has spurred interest in the development of efficient methods to generate large numbers of T cells with specificity for tumor antigens that can be harnessed for use in cancer therapy. Recent studies have demonstrated that during encounter with tumor antigen, the signals delivered to T cells by professional antigen-presenting cells can affect T-cell programming and their subsequent therapeutic efficacy. This has stimulated efforts to develop artificial antigen-presenting cells that allow optimal control over the signals provided to T cells. In this review, we will discuss the advantages and disadvantages of cellular and acellular artificial antigen-presenting cell systems and their use in T-cell adoptive immunotherapy for cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation
  • Antigen-Presenting Cells / immunology*
  • Artificial Cells / immunology*
  • Cell Line, Tumor
  • Humans
  • Immunotherapy, Adoptive / methods*
  • Neoplasms / immunology*
  • Neoplasms / therapy*