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Urology. 2010 Nov;76(5):1206-9. doi: 10.1016/j.urology.2010.03.090. Epub 2010 Aug 8.

Tumor grade at margins of resection in radical prostatectomy specimens is an independent predictor of prognosis.

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  • 1Department of Pathology, Johns Hopkins Hospital Medical Institutions, Baltimore, Maryland, USA.

Abstract

OBJECTIVES:

To assess whether reporting the grade of cancer at the site of positive margins in a radical prostatectomy (RP) specimen was independently prognostic of the outcome.

METHODS:

We restricted our study to 108 patients with Gleason score (GS) 7, nonfocal extraprostatic extension (EPE) (Stage pT3a), and positive surgical margins. Patients with a tertiary pattern 5, those who had received neoadjuvant therapy, and those with positive margins because of an intraprostatic incision were excluded.

RESULTS:

The overall GS was 3 + 4 in 73 patients (67%) and 4 + 3 in 35 (33%). The median length of the positive margin was 3.0 mm (range 0.5-10). The GS at the margin was 3 + 3, 3 + 4, 4 + 3, and 4 + 4 in 40 (37%), 41 (38%), 16 (14.8%), and 11 (10.2%) cases, respectively. Of the 108 patients, 45 (42%) remained free of disease after RP (median follow-up 6 years, range 3-13). Univariate and multivariate analyses showed no correlation between biochemical recurrence and either the preoperative serum prostate-specific antigen level (P = .7) or overall GS (P = .5). A strong association was noted between biochemical recurrence and the GS at the positive surgical margin (P = .007), with length of cancer at the margin also predictive (P = .015) on multivariate analysis. Using the median length of the positive margin (3 mm) as the cutoff, the association with biochemical recurrence was significantly different between the 2 groups (P = .004) using Kaplan-Meier analysis.

CONCLUSIONS:

This is the first study to show that the grade of cancer at the site of a positive margin influences the outcome. We were able to stratify the grade into 3 categories: 3 + 3, 3 + 4, and 4 + 3 or greater (4 + 3 and 4 + 4 at the positive margin provided equal prognostic information).

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
20692688
[PubMed - indexed for MEDLINE]
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