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Am J Obstet Gynecol. 2010 Oct;203(4):366.e1-6. doi: 10.1016/j.ajog.2010.06.036. Epub 2010 Aug 8.

Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia.

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  • 1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC, USA.

Abstract

OBJECTIVE:

Vitamin D deficiency has been linked to adverse pregnancy outcomes. The purpose of this investigation was to assess total 25-hydroxyvitamin D (25-OH-D) levels at diagnosis of early-onset severe preeclampsia (EOSPE).

STUDY DESIGN:

After institutional review board approval, we enrolled subjects with EOSPE (<34 weeks' gestation with severe preeclampsia) in this case-control investigation in a 1:2 ratio with gestation-matched, contemporaneous control subjects. Demographic and outcome information was collected for each subject. Plasma total 25-OH-D levels were determined by radioimmunoassay and reported in nanograms per milliliter. Results were analyzed by Mann-Whitney U and multivariable regression.

RESULTS:

Subjects with EOSPE (n = 50) were noted to have decreased total 25-OH-D levels relative to healthy control subjects (n = 100; P < .001). This difference in total 25-OH-D remained significant after control for potential confounders.

CONCLUSION:

Total 25-OH-D is decreased at diagnosis of EOSPE. Further study is needed to understand the impact of vitamin D deficiency on pregnancy outcomes.

Copyright © 2010 Mosby, Inc. All rights reserved.

PMID:
20692641
[PubMed - indexed for MEDLINE]
PMCID:
PMC3192365
Free PMC Article

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