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Cell. 2010 Aug 6;142(3):368-74. doi: 10.1016/j.cell.2010.07.022.

The pioneer round of translation: features and functions.

Author information

  • 1Department of Biochemistry and Biophysics and Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. lynne_maquat@urmc.rochester.edu


In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.

Copyright 2010 Elsevier Inc. All rights reserved.

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