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Microbes Infect. 2010 Dec;12(14-15):1091-101. doi: 10.1016/j.micinf.2010.07.014. Epub 2010 Aug 5.

Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence.

Author information

  • 1Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Mycobacterium tuberculosis is an obligate human intracellular pathogen which remains a major killer worldwide. A remarkable feature of M. tuberculosis infection is the ability of the pathogen to persist within the host for decades despite an impressive onslaught of stresses. In this review we seek to outline the host-inflicted stresses experienced by M. tuberculosis, the bacterial strategies used to withstand these stresses, and how this information should guide our efforts to combat this global pathogen.

Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved.

PMID:
20691805
[PubMed - indexed for MEDLINE]
PMCID:
PMC3587153
Free PMC Article
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